Plone
A powerful, flexible Content Management solution that is easy to install, use and extend
Plone lets non-technical people create and maintain information for a public website or an intranet using only a web browser. Plone is easy to understand and use — allowing users to be productive in just half an hour — yet offers a wealth of community-developed add-ons and extensibility to keep meeting your needs for years to come.Click here for further detail
Skeletonz
Skeletonz is a new content management system (CMS) based on Python. It differs from others by being simple, but yet very powerful and extensible. If you need a simple system that you and your users are going love then Skeletonz might be the solution you are looking for! The system is open source and released under GNU GPL.
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MediaCore Video CMS
MediaCore Video CMS is an open source media focused content management system. It features video & audio support, YouTube & Vimeo integration, podcasting, iTunes RSS generation, user-submitted content, embedded media player, wysiwg edior, search, and is highly customizable. There is both a front-end for users and a back-end for administrators. It is built upon TurboGears, SQLAlchemy, MYSQL and runs with Apache, Fast_CGI or Mod_WSGI.
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PyLucid
PyLucid is a lightweight CMS written in Python WSGI. No shell account is needed. To run PyLucid you need a standard Web server with Python (at least v2.3), CGI and mySQLdb.
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Django - CMS
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